Planning sine waves electroporation on liposomes for drug delivery application

Radiofrequency (RF) signals as a way to remotely control smart drug delivery nanocarriers represent a promising tool to overcome traditional therapeutic issues, such as overdosing therapeutic agents with a reduced efficacy and related side effects on healthy tissues, in order to obtain a targeted release near diseased cells. Aim of this work is to provide a deep investigation on the possible effect of sine wave RF signals, of 100 kHz and 10 MHz, applied to a non-uniform random distribution of 142 liposomes, as a realistic model of a biocompatible drug delivery suspension, to study electroporation mechanisms occurring during exposure.